PRODUCTS The HYDAK® Process HYDAK is Biocoat's registered trademark for its immobilized hyaluronan coatings technology. Application of the HYDAK Coatings is a relatively simple process using conventional coating equipment and curing ovens. Usually coatings are applied by dip-coating. HYDAK Coatings can be used on both inside and outside surfaces and on most commonly used polymers and metals. HYDAK Advantages Exceptionally hydrophilic Lubricious when wet, preventing trauma and tissue abrasion Abrasion resistant Very thin, flexible coatings can be applied Biocompatible Non-thrombogenic Prevents adhesion of platelets, proteins, microorganisms Carrier for bioactive substances to make anti-bacterial surfaces anti-thrombogenic surfaces HYDAK-coated surfaces exhibit a marked reduction or absence of: adsorbed platelets proteins bacteria acute thrombus formation Process Steps Pre-treatment A simple solvent cleaning suffices for most substrates Apply First Coat Adhesive polymer coating, either water-based or in organic solvent Dry First Coat Usually 10-20 minutes in 60°C oven Apply Second Coat Aqueous solution of hyaluronan Cure Bilaminar Coat 1-2 hours in 60-70°C oven Washing/Drying To remove unreacted hyaluronan and unreactive or water soluble additives Sterilization Ethylene oxide recommended HYDAK Biocompatibility As one might expect for a material that is ubiquitous in the body, the biocompatibility of hyaluronan-modified surfaces has been well-established and confirmed by in vitro and in vivo tests including: cytotoxicity hemolysis acute systemic toxicity intracutaneous toxicity muscle implantation dermal irritation genotoxicity HYDAK Properties The HYDAK system of coatings affords great flexibility in tailoring biocompatible surfaces to the requirements of medical device applications. Physical properties are readily adapted to meet the design criteria of medical device applications: thickness wettability lubricity flexibility abrasion resistance storage stability HYDAK Applications The HYDAK system of coatings is versatile and has applications in a wide variety of medical fields. Medical devices on the market already employ this technology, and new types of devices that require hydrophilic coatings and biocompatible surfaces are constantly arising. Possible applications include: Catheters Micro-catheters Guide Wires Balloons Introducers Sheaths Lead Wires Intraocular (IOL) Cartridges Endoscopes Vertebral Cages Meshes Blood contacting surfaces that require antithrombogenicity Sliding surfaces that require lubricity HYDAK Top Coats and Base Coats Click on the buttons below for more information.               Biocoat, Inc. 211 Witmer Road, Horsham, PA 19044 Tel: 215-734-0888   Fax: 215-734-0889 Home   |   About Biocoat   |   Products   |   Services   |   News   |   Downloads   |   Contact Us   |   Site Map