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The HYDAK® Process

HYDAK is Biocoat's registered trademark for its immobilized hyaluronan coatings technology. Application of the HYDAK Coatings is a relatively simple process using conventional coating equipment and curing ovens. Usually coatings are applied by dip-coating. HYDAK Coatings can be used on both inside and outside surfaces and on most commonly used polymers and metals.

HYDAK Advantages
  • Exceptionally hydrophilic
  • Lubricious when wet, preventing trauma and tissue abrasion
  • Abrasion resistant
  • Very thin, flexible coatings can be applied
  • Biocompatible
  • Non-thrombogenic
  • Prevents adhesion of platelets, proteins, microorganisms
  • Carrier for bioactive substances to make
    • anti-bacterial surfaces
    • anti-thrombogenic surfaces
HYDAK-coated surfaces exhibit a marked reduction or absence of:
  • adsorbed platelets
  • proteins
  • bacteria
  • acute thrombus formation
Process Steps

Pre-treatment
A simple solvent cleaning suffices for most substrates
Apply First Coat
Adhesive polymer coating, either water-based or in organic solvent
Dry First Coat
Usually 10-20 minutes in 60°C oven
Apply Second Coat
Aqueous solution of hyaluronan
Cure Bilaminar Coat
1-2 hours in 60-70°C oven
Washing/Drying
To remove unreacted hyaluronan and unreactive or water soluble additives
Sterilization
Ethylene oxide recommended


HYDAK Biocompatibility

As one might expect for a material that is ubiquitous in the body, the biocompatibility of hyaluronan-modified surfaces has been well-established and confirmed by in vitro and in vivo tests including:
  • cytotoxicity
  • hemolysis
  • acute systemic toxicity
  • intracutaneous toxicity
  • muscle implantation
  • dermal irritation
  • genotoxicity

HYDAK Properties

The HYDAK system of coatings affords great flexibility in tailoring biocompatible surfaces to the requirements of medical device applications.

Physical properties are readily adapted to meet the design criteria of medical device applications:
  • thickness
  • wettability
  • lubricity
  • flexibility
  • abrasion resistance
  • storage stability

HYDAK Applications

The HYDAK system of coatings is versatile and has applications in a wide variety of medical fields. Medical devices on the market already employ this technology, and new types of devices that require hydrophilic coatings and biocompatible surfaces are constantly arising. Possible applications include:

  • Catheters
  • Micro-catheters
  • Guide Wires
  • Balloons
  • Introducers
  • Sheaths
  • Lead Wires
  • Intraocular (IOL) Cartridges
  • Endoscopes
  • Vertebral Cages
  • Meshes
  • Blood contacting surfaces that require antithrombogenicity
  • Sliding surfaces that require lubricity

HYDAK Top Coats and Base Coats

Click on the buttons below for more information.

             



Biocoat, Inc.
211 Witmer Road, Horsham, PA 19044
Tel: 215-734-0888   Fax: 215-734-0889

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